When wounded skin begins to heal, the body sends cells known as fibroblasts to produce collagen protein fibers to grow over the injury. The collagen fibers that fibroblasts create are the same as in healthy body tissue, but their proliferation in the wound healing process frequently leads to a different appearance in the resultant tissue. As collagen grows quickly within the wound, the fibers can easily contract and change the organization of the tissue components.
To address this change in structural organization, scar therapy treatments frequently include an ingredient that inhibits transforming growth factor (TGF), one of the causes of rapid collagen growth. This allows the collagen to grow over the wound more slowly and in the normal woven manner. Scar therapy creams may also include an anti-inflammatory and an anti-histamine to reduce swelling, which further supports normal tissue growth and increases comfort for the patient.